TUNON-OAB · PRODUCT BRIEF Non-invasive Tibial Nerve Stimulation for OAB
01 — About OAB
Overactive Bladder
When the sudden urge to urinate takes over daily life
Urgency without infection or obvious pathology, usually with frequency and nocturia — affecting roughly 1 in 6 US adults. (ICS definition; AUA/SUFU 2024; NOBLE, Stewart 2003)
Urgency
Frequency · ≥8 / day
Nocturia · ≥1 / night
Urgency incontinence
Overactive bladder measurably worsens sleep. In a US survey of 5,204 adults, sleep quality was significantly poorer in people with OAB than in matched controls.
Stewart WF et al., World J Urol 2003;20:327–336 (NOBLE Program).
Yet drug therapy rarely lasts. Only ~22% of patients remain on medication at 12 months, and cumulative use of antimuscarinics has been linked to cognitive concerns.
Song YS et al., J Urol 2021;205:1595–1604 (persistence); Iyen B et al., BMJ Med 2024 (cognition).
02 — The Therapy
Tibial Nerve Stimulation
An established option beyond drug therapy
The posterior tibial nerve shares its spinal origin (L4–S3) with the sacral nerves that govern the bladder.
Stimulating it at 20 Hz modulates the overactive voiding reflex, easing urgency and frequency.
Tibial nerve stimulation is a guideline-recommended therapy for overactive bladder.
AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive Bladder (2024) — Statement 25, Moderate Recommendation, Evidence Level Grade A. The recommendation applies to the therapy, not to any specific investigational device.
Standard treatment protocol
STEP 1
Initial therapy
30-min session, weekly, for 12 weeks
STEP 2
Assessment
Response assessed after the full 12 sessions
STEP 3
Maintenance
Continues at widening intervals, indefinitely
Urgent® PC Neuromodulation System, Instructions for Use — treatment frequency and maintenance schedule.
To date, tibial nerve stimulation has been delivered through a percutaneous needle, or through an implanted device.
03 — Mechanism
How TUNON-OAB Targets the Tibial Nerve
Focused stimulation with precision
Non-invasive — three or more (n) current sources, with a mathematical correction driving their sum to zero. Reaches the deep tibial nerve without a needle.
Precise targeting — the user steers the focus by adjusting current amplitude and phase, aligning it with the target nerve.
Low surface current — cancelling the summed current between multi-phase electrodes minimises leakage, reducing unnecessary stimulation at the skin surface.
04 — Configuration
Product Configuration
Stimulator, band electrode, and on-device touchscreen control
6-channel constant-current band electrode — 2 networks × 3 channels each
Anatomically designed for repeatable tibial nerve targeting
Breathable fabric for comfortable extended wear
Jog dial to steer the focus and adjust intensity
10-inch touchscreen with a guided interface
Independent constant-current control on each channel, sinusoidal waveform
05 — Positioning
Comparison by Approach
TUNON-OAB compared with existing approaches
Percutaneous, needle
Conventional surface
Implantable
TUNON-OABMulti-phase TIS
Invasiveness
Needle
Non-invasive
Surgery
Fully non-invasive
Setting
In-clinic
Home
Home
Home, self-use
Depth of stimulation
Needle reaches the nerve
Shallow and variable
Fixed by the implant
Deep focus by interference
Ongoing burden
A clinic visit each session
None
Surgery to replace the battery
Initial prescription visit only
TUNON-OAB uses surface electrodes too — but instead of driving a single frequency into the skin, it forms a focus at depth through interference between two carriers. That is why it does not stop at the surface.
TUNON-OAB makes no new claim of efficacy. What it changes is delivery — bringing a recommended therapy home. No needle. No surgery.
